BRD-K04887706_AKT-inhibitor-1-2_SKBR3_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C10ORF10 chromosome 10 open reading frame 10
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DPEP1 dipeptidase 1 (renal)
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JADE2 jade family PHD finger 2
KDM4B lysine (K)-specific demethylase 4B
LDLR low density lipoprotein receptor
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PTGES prostaglandin E synthase
REG3A regenerating islet-derived 3 alpha
RPL27A ribosomal protein L27a
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SRGN serglycin
UGCG UDP-glucose ceramide glucosyltransferase
VEGFA vascular endothelial growth factor A
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
CADM1 cell adhesion molecule 1
CYR61 cysteine-rich, angiogenic inducer, 61
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FRZB frizzled-related protein
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
L1CAM L1 cell adhesion molecule
LPAR1 lysophosphatidic acid receptor 1
MYLK myosin light chain kinase
NPY neuropeptide Y
PDE4DIP phosphodiesterase 4D interacting protein
PMM2 phosphomannomutase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
SCG5 secretogranin V
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TSPAN1 tetraspanin 1
WFDC2 WAP four-disulfide core domain 2
Funding