BRD-K05104363_PD-184352_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K05104363_PD-184352_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AUTS2 autism susceptibility candidate 2
C5 complement component 5
CAT catalase
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DEFB1 defensin, beta 1
ECHDC2 enoyl CoA hydratase domain containing 2
EFNA1 ephrin-A1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS2 fatty acid desaturase 2
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HP haptoglobin
HSDL2 hydroxysteroid dehydrogenase like 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGSF3 immunoglobulin superfamily, member 3
KDM5D lysine (K)-specific demethylase 5D
KLHL9 kelch-like family member 9
LIMCH1 LIM and calponin homology domains 1
LYST lysosomal trafficking regulator
METTL7A methyltransferase like 7A
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
SC5D sterol-C5-desaturase
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SETBP1 SET binding protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SYNGR3 synaptogyrin 3
TCTA T-cell leukemia translocation altered
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
TTC3 tetratricopeptide repeat domain 3
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOA aldolase A, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
BAG2 BCL2-associated athanogene 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE40 basic helix-loop-helix family, member e40
BOP1 block of proliferation 1
CEMIP cell migration inducing protein, hyaluronan binding
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRLF1 cytokine receptor-like factor 1
CTGF connective tissue growth factor
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPY19L1 dpy-19-like 1 (C. elegans)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EBNA1BP2 EBNA1 binding protein 2
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
EREG epiregulin
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FAT1 FAT atypical cadherin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
INPP1 inositol polyphosphate-1-phosphatase
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LIF leukemia inhibitory factor
LIMS1 LIM and senescent cell antigen-like domains 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MYCBP MYC binding protein
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PUS7 pseudouridylate synthase 7 (putative)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLIRP SRA stem-loop interacting RNA binding protein
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
STK39 serine threonine kinase 39
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TPM2 tropomyosin 2 (beta)
VCAN versican
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