BRD-K05104363_PD-184352_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K05104363_PD-184352_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLVRB biliverdin reductase B
BST2 bone marrow stromal cell antigen 2
CD59 CD59 molecule, complement regulatory protein
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CXCL13 chemokine (C-X-C motif) ligand 13
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DUSP10 dual specificity phosphatase 10
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLRT3 fibronectin leucine rich transmembrane protein 3
GAB2 GRB2-associated binding protein 2
GSTP1 glutathione S-transferase pi 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT16 keratin 16, type I
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NXN nucleoredoxin
PDIA5 protein disulfide isomerase family A, member 5
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RAB38 RAB38, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
TSC22D3 TSC22 domain family, member 3
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL11 chemokine (C-X-C motif) ligand 11
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV1 ets variant 1
F5 coagulation factor V (proaccelerin, labile factor)
FEN1 flap structure-specific endonuclease 1
FKBP1A FK506 binding protein 1A, 12kDa
FOSL1 FOS-like antigen 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGB1BP1 integrin beta 1 binding protein 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NET1 neuroepithelial cell transforming 1
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PDE8B phosphodiesterase 8B
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RFC2 replication factor C (activator 1) 2, 40kDa
RGS17 regulator of G-protein signaling 17
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SPRY2 sprouty homolog 2 (Drosophila)
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TMEM194A transmembrane protein 194A
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
ZWINT ZW10 interacting kinetochore protein
Funding