BRD-K05104363_PD-184352_HT29_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K05104363_PD-184352_HT29_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTN3A2 butyrophilin, subfamily 3, member A2
C1RL complement component 1, r subcomponent-like
CAT catalase
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CFD complement factor D (adipsin)
CLCA1 chloride channel accessory 1
CXADR coxsackie virus and adenovirus receptor
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GRAMD3 GRAM domain containing 3
GRN granulin
GSN gelsolin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KLF5 Kruppel-like factor 5 (intestinal)
MAGEA3 melanoma antigen family A3
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
N4BP2L1 NEDD4 binding protein 2-like 1
NAP1L3 nucleosome assembly protein 1-like 3
NBR1 neighbor of BRCA1 gene 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PHF20 PHD finger protein 20
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RAB40B RAB40B, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSRP1 arginine/serine-rich protein 1
SCCPDH saccharopine dehydrogenase (putative)
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC35E2B solute carrier family 35, member E2B
SNX2 sorting nexin 2
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STXBP1 syntaxin binding protein 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TM7SF2 transmembrane 7 superfamily member 2
TOX thymocyte selection-associated high mobility group box
TP53TG1 TP53 target 1 (non-protein coding)
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TSPAN3 tetraspanin 3
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB10 zinc finger and BTB domain containing 10
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AEBP1 AE binding protein 1
AGTR1 angiotensin II receptor, type 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
AURKA aurora kinase A
BOP1 block of proliferation 1
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPU centromere protein U
CHN1 chimerin 1
CKLF chemokine-like factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IER2 immediate early response 2
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
KIAA0020 KIAA0020
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MMP9 matrix metallopeptidase 9
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NPTX2 neuronal pentraxin II
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SQRDL sulfide quinone reductase-like (yeast)
SRM spermidine synthase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
UPP1 uridine phosphorylase 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZDHHC6 zinc finger, DHHC-type containing 6
Funding