BRD-K05331696_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K05331696_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMOTL2 angiomotin like 2
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP11B ATPase, class VI, type 11B
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CALR calreticulin
CBR3 carbonyl reductase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTTN cortactin
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
ERP29 endoplasmic reticulum protein 29
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GBP2 guanylate binding protein 2, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LDLR low density lipoprotein receptor
LY6E lymphocyte antigen 6 complex, locus E
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
RCAN1 regulator of calcineurin 1
RIT1 Ras-like without CAAX 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SELL selectin L
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
TKT transketolase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOX3 TOX high mobility group box family member 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
ARMCX1 armadillo repeat containing, X-linked 1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CDR2L cerebellar degeneration-related protein 2-like
CHRDL1 chordin-like 1
CXCL5 chemokine (C-X-C motif) ligand 5
DEPTOR DEP domain containing MTOR-interacting protein
EFNA1 ephrin-A1
EPN2 epsin 2
FHL1 four and a half LIM domains 1
GATA2 GATA binding protein 2
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
LXN latexin
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
NUP85 nucleoporin 85kDa
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
SELENBP1 selenium binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TGFB3 transforming growth factor, beta 3
Funding