BRD-K05402890_NCGC00165289-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K05402890_NCGC00165289-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ASMTL acetylserotonin O-methyltransferase-like
BAG2 BCL2-associated athanogene 2
CAPN2 calpain 2, (m/II) large subunit
CLIC5 chloride intracellular channel 5
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPI glucose-6-phosphate isomerase
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
ITGB5 integrin, beta 5
KIAA0355 KIAA0355
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
PAWR PRKC, apoptosis, WT1, regulator
PCDH9 protocadherin 9
PDLIM3 PDZ and LIM domain 3
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
S100A9 S100 calcium binding protein A9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX11 SRY (sex determining region Y)-box 11
TPM1 tropomyosin 1 (alpha)
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AGR2 anterior gradient 2
ARMCX1 armadillo repeat containing, X-linked 1
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
EAPP E2F-associated phosphoprotein
EGR3 early growth response 3
ESR1 estrogen receptor 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST3H2A histone cluster 3, H2a
HMGN3 high mobility group nucleosomal binding domain 3
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KLHL21 kelch-like family member 21
KRT19 keratin 19, type I
MANSC1 MANSC domain containing 1
MELK maternal embryonic leucine zipper kinase
MPC2 mitochondrial pyruvate carrier 2
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
NBN nibrin
NPY1R neuropeptide Y receptor Y1
OLFM1 olfactomedin 1
PCNA proliferating cell nuclear antigen
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE4 ribonuclease, RNase A family, 4
SELT selenoprotein T
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOX4 SRY (sex determining region Y)-box 4
TM7SF2 transmembrane 7 superfamily member 2
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
VCAM1 vascular cell adhesion molecule 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
Funding