BRD-K05452595_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K05452595_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
BAG3 BCL2-associated athanogene 3
C6ORF48 chromosome 6 open reading frame 48
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2A cyclin-dependent kinase inhibitor 2A
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
GCLM glutamate-cysteine ligase, modifier subunit
GPER1 G protein-coupled estrogen receptor 1
GRAMD3 GRAM domain containing 3
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IQGAP2 IQ motif containing GTPase activating protein 2
KYNU kynureninase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAMLD1 mastermind-like domain containing 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBD thrombomodulin
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ADA adenosine deaminase
ANGPT2 angiopoietin 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CD1D CD1d molecule
CD1E CD1e molecule
CD9 CD9 molecule
CD93 CD93 molecule
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
GJA1 gap junction protein, alpha 1, 43kDa
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HEBP2 heme binding protein 2
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
JCHAIN joining chain of multimeric IgA and IgM
MTCL1 microtubule crosslinking factor 1
NFE2 nuclear factor, erythroid 2
NNMT nicotinamide N-methyltransferase
ORC1 origin recognition complex, subunit 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STAB1 stabilin 1
TGFB1 transforming growth factor, beta 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF586 zinc finger protein 586
Funding