BRD-K05562558_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K05562558_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
BEX1 brain expressed, X-linked 1
CHI3L2 chitinase 3-like 2
COTL1 coactosin-like F-actin binding protein 1
DLK1 delta-like 1 homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITFG1 integrin alpha FG-GAP repeat containing 1
LY86 lymphocyte antigen 86
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
P3H2 prolyl 3-hydroxylase 2
PCP4 Purkinje cell protein 4
PDE4D phosphodiesterase 4D, cAMP-specific
PEG3 paternally expressed 3
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PRKCB protein kinase C, beta
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A4 solute carrier family 16, member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ANO1 anoctamin 1, calcium activated chloride channel
BAMBI BMP and activin membrane-bound inhibitor
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
DEPTOR DEP domain containing MTOR-interacting protein
IFI27 interferon, alpha-inducible protein 27
LAPTM4B lysosomal protein transmembrane 4 beta
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NFIB nuclear factor I/B
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PODXL podocalyxin-like
PSPH phosphoserine phosphatase
SPINK1 serine peptidase inhibitor, Kazal type 1
THBS1 thrombospondin 1
ZFP36L2 ZFP36 ring finger protein-like 2
Funding