BRD-K05649647_-666_A375_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K05649647_-666_A375_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BET1 Bet1 golgi vesicular membrane trafficking protein
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRELD2 cysteine-rich with EGF-like domains 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GLRX glutaredoxin (thioltransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
HAX1 HCLS1 associated protein X-1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
LARP6 La ribonucleoprotein domain family, member 6
LRRC59 leucine rich repeat containing 59
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MTFR1 mitochondrial fission regulator 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGM3 phosphoglucomutase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
SARS seryl-tRNA synthetase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SUCO SUN domain containing ossification factor
TES testin LIM domain protein
TJP1 tight junction protein 1
TMED2 transmembrane emp24 domain trafficking protein 2
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMACR alpha-methylacyl-CoA racemase
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
NUP62 nucleoporin 62kDa
PLK1 polo-like kinase 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGM2 transglutaminase 2
TUBB4B tubulin, beta 4B class IVb