BRD-K05804044_AZ-628_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

312 genes differentially expressed following the BRD-K05804044_AZ-628_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANGPT1 angiopoietin 1
ANXA4 annexin A4
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTBD3 BTB (POZ) domain containing 3
C14ORF132 chromosome 14 open reading frame 132
C14ORF159 chromosome 14 open reading frame 159
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAPN3 calpain 3, (p94)
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFB complement factor B
CKB creatine kinase, brain
CLDN10 claudin 10
CLIP3 CAP-GLY domain containing linker protein 3
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL21A1 collagen, type XXI, alpha 1
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAPK1 death-associated protein kinase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
DHCR24 24-dehydrocholesterol reductase
DHRS1 dehydrogenase/reductase (SDR family) member 1
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FDXR ferredoxin reductase
FGFR3 fibroblast growth factor receptor 3
FNBP1 formin binding protein 1
GABARAP GABA(A) receptor-associated protein
GAS1 growth arrest-specific 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HMGN3 high mobility group nucleosomal binding domain 3
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
JUN jun proto-oncogene
KAZN kazrin, periplakin interacting protein
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMB2 laminin, beta 2 (laminin S)
LCN2 lipocalin 2
LIMK2 LIM domain kinase 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LMOD1 leiomodin 1 (smooth muscle)
LTBP1 latent transforming growth factor beta binding protein 1
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
METRN meteorin, glial cell differentiation regulator
MN1 meningioma (disrupted in balanced translocation) 1
MVP major vault protein
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NDRG2 NDRG family member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM4 PDZ and LIM domain 4
PHYH phytanoyl-CoA 2-hydroxylase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLP1 proteolipid protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
PTN pleiotrophin
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RABAC1 Rab acceptor 1 (prenylated)
RALGDS ral guanine nucleotide dissociation stimulator
RBKS ribokinase
REEP1 receptor accessory protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCRG1 stimulator of chondrogenesis 1
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SSFA2 sperm specific antigen 2
SSPN sarcospan
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYT11 synaptotagmin XI
TAC1 tachykinin, precursor 1
TAGLN transgelin
TM7SF2 transmembrane 7 superfamily member 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM135 transmembrane protein 135
TNS1 tensin 1
TOB2 transducer of ERBB2, 2
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TSPYL4 TSPY-like 4
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNL4B thioredoxin-like 4B
VAT1 vesicle amine transport 1
VGLL4 vestigial-like family member 4
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
CAPN15 calpain 15
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST7 cystatin F (leukocystatin)
CYBB cytochrome b-245, beta polypeptide
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO1 enolase 1, (alpha)
ENOPH1 enolase-phosphatase 1
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV4 ets variant 4
EXOSC2 exosome component 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTPBP4 GTP binding protein 4
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL2RG interleukin 2 receptor, gamma
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
LMNB1 lamin B1
LPL lipoprotein lipase
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICB MHC class I polypeptide-related sequence B
MMP9 matrix metallopeptidase 9
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RNF126 ring finger protein 126
RNF6 ring finger protein (C3H2C3 type) 6
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCML1 sex comb on midleg-like 1 (Drosophila)
SEH1L SEH1-like (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMPO thymopoietin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
WDR3 WD repeat domain 3
WSB2 WD repeat and SOCS box containing 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
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