BRD-K05804044_AZ-628_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K05804044_AZ-628_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM12 ADAM metallopeptidase domain 12
ALCAM activated leukocyte cell adhesion molecule
ANO10 anoctamin 10
BAMBI BMP and activin membrane-bound inhibitor
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CEMIP cell migration inducing protein, hyaluronan binding
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN10 claudin 10
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DENND5A DENN/MADD domain containing 5A
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLK1 delta-like 1 homolog (Drosophila)
EDN1 endothelin 1
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GLS glutaminase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
HSPB8 heat shock 22kDa protein 8
ITGAV integrin, alpha V
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LMCD1 LIM and cysteine-rich domains 1
LYZ lysozyme
MB myoglobin
METRN meteorin, glial cell differentiation regulator
MGST3 microsomal glutathione S-transferase 3
MYBPC1 myosin binding protein C, slow type
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PON2 paraoxonase 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SGCE sarcoglycan, epsilon
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TACC1 transforming, acidic coiled-coil containing protein 1
TMOD1 tropomodulin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

decreased expression

Symbol Name
CD163 CD163 molecule
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DUSP6 dual specificity phosphatase 6
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX3 glutathione peroxidase 3
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP1 insulin-like growth factor binding protein 1
KLK5 kallikrein-related peptidase 5
MMP9 matrix metallopeptidase 9
NRN1 neuritin 1
PDGFD platelet derived growth factor D
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RNF167 ring finger protein 167
TFPI2 tissue factor pathway inhibitor 2
VNN1 vanin 1
ZNF91 zinc finger protein 91
Funding