BRD-K05870596_XMD-1499_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K05870596_XMD-1499_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CFD complement factor D (adipsin)
COPS7A COP9 signalosome subunit 7A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
FBP1 fructose-1,6-bisphosphatase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA6 GATA binding protein 6
GRB10 growth factor receptor-bound protein 10
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IDS iduronate 2-sulfatase
KRT18 keratin 18, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAP2K5 mitogen-activated protein kinase kinase 5
MMP7 matrix metallopeptidase 7
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRP1 neuropilin 1
PALLD palladin, cytoskeletal associated protein
PLSCR3 phospholipid scramblase 3
PPIC peptidylprolyl isomerase C (cyclophilin C)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RND3 Rho family GTPase 3
S100A11 S100 calcium binding protein A11
SC5D sterol-C5-desaturase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRGN serglycin
STC1 stanniocalcin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TPM2 tropomyosin 2 (beta)
YES1 YES proto-oncogene 1, Src family tyrosine kinase

decreased expression

Symbol Name
CA2 carbonic anhydrase II
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
FZD5 frizzled class receptor 5
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HMGB2 high mobility group box 2
LHX2 LIM homeobox 2
LIG1 ligase I, DNA, ATP-dependent
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCM5 minichromosome maintenance complex component 5
MYO1D myosin ID
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PRKCB protein kinase C, beta
PXMP2 peroxisomal membrane protein 2, 22kDa
RGCC regulator of cell cycle
S100A9 S100 calcium binding protein A9
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
ZNF266 zinc finger protein 266
Funding