BRD-K06426971_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K06426971_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
AGTPBP1 ATP/GTP binding protein 1
ARF6 ADP-ribosylation factor 6
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CCNA1 cyclin A1
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EAF2 ELL associated factor 2
EGR1 early growth response 1
EGR3 early growth response 3
EHD3 EH-domain containing 3
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF15 growth differentiation factor 15
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
LRRC15 leucine rich repeat containing 15
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCAN1 regulator of calcineurin 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
BCHE butyrylcholinesterase
CCNF cyclin F
CYC1 cytochrome c-1
FAM129A family with sequence similarity 129, member A
HSPA1A heat shock 70kDa protein 1A
IFRD2 interferon-related developmental regulator 2
IQGAP2 IQ motif containing GTPase activating protein 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LIMA1 LIM domain and actin binding 1
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
TMX4 thioredoxin-related transmembrane protein 4
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)