BRD-K06543683_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K06543683_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
CALD1 caldesmon 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CFB complement factor B
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
FGG fibrinogen gamma chain
FLOT1 flotillin 1
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HEBP1 heme binding protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
ISG15 ISG15 ubiquitin-like modifier
LOXL2 lysyl oxidase-like 2
MEIS2 Meis homeobox 2
MLF1 myeloid leukemia factor 1
MSN moesin
MX1 MX dynamin-like GTPase 1
NELL2 NEL-like 2 (chicken)
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PNMA2 paraneoplastic Ma antigen 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SH3BGR SH3 domain binding glutamate-rich protein
SMYD3 SET and MYND domain containing 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD2 C2 calcium-dependent domain containing 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHIC2 cysteine-rich hydrophobic domain 2
CHSY1 chondroitin sulfate synthase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST3 cystatin C
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EED embryonic ectoderm development
ELF1 E74-like factor 1 (ets domain transcription factor)
FADD Fas (TNFRSF6)-associated via death domain
FASTKD5 FAST kinase domains 5
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KYNU kynureninase
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MED17 mediator complex subunit 17
MFSD5 major facilitator superfamily domain containing 5
MRPS30 mitochondrial ribosomal protein S30
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCD protein kinase C, delta
PSPC1 paraspeckle component 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF6 ring finger protein (C3H2C3 type) 6
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEFM transcription elongation factor, mitochondrial
TEX10 testis expressed 10
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
THUMPD1 THUMP domain containing 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM2D3 TM2 domain containing 3
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRAF4 TNF receptor-associated factor 4
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXNL4B thioredoxin-like 4B
UBE2S ubiquitin-conjugating enzyme E2S
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
Funding