BRD-K06569345_HG-5-88-01_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K06569345_HG-5-88-01_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5 arachidonate 5-lipoxygenase
ARHGAP6 Rho GTPase activating protein 6
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF61 chromosome 1 open reading frame 61
C2CD2 C2 calcium-dependent domain containing 2
CFP complement factor properdin
CLU clusterin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CYBB cytochrome b-245, beta polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DYNLT3 dynein, light chain, Tctex-type 3
EML3 echinoderm microtubule associated protein like 3
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGF13 fibroblast growth factor 13
FOXG1 forkhead box G1
FRY furry homolog (Drosophila)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GNLY granulysin
GRIA2 glutamate receptor, ionotropic, AMPA 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBB hemoglobin, beta
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT19 keratin 19, type I
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
LIMS1 LIM and senescent cell antigen-like domains 1
LOC100505650 uncharacterized LOC100505650
MAP3K7CL MAP3K7 C-terminal like
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MUC16 mucin 16, cell surface associated
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PRF1 perforin 1 (pore forming protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTN pleiotrophin
QPCT glutaminyl-peptide cyclotransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SALL1 spalt-like transcription factor 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIDT2 SID1 transmembrane family, member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SORBS2 sorbin and SH3 domain containing 2
SSBP2 single-stranded DNA binding protein 2
TBL1X transducin (beta)-like 1X-linked
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TMOD1 tropomodulin 1
TMPRSS3 transmembrane protease, serine 3
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
ZNF365 zinc finger protein 365

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACAA2 acetyl-CoA acyltransferase 2
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CCND1 cyclin D1
CD200 CD200 molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CRABP2 cellular retinoic acid binding protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DUSP6 dual specificity phosphatase 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HIST1H2BD histone cluster 1, H2bd
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
INHBB inhibin, beta B
JADE2 jade family PHD finger 2
KRT14 keratin 14, type I
MAGED2 melanoma antigen family D2
MALL mal, T-cell differentiation protein-like
MT1F metallothionein 1F
MYO1B myosin IB
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRDX4 peroxiredoxin 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHB Src homology 2 domain containing adaptor protein B
SLPI secretory leukocyte peptidase inhibitor
SOX10 SRY (sex determining region Y)-box 10
STK10 serine/threonine kinase 10
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLK2 tousled-like kinase 2
TSPAN3 tetraspanin 3
Funding