BRD-K06666320_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

201 genes differentially expressed following the BRD-K06666320_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADAM8 ADAM metallopeptidase domain 8
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALB albumin
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BPI bactericidal/permeability-increasing protein
C3 complement component 3
C5ORF15 chromosome 5 open reading frame 15
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHMP2A charged multivesicular body protein 2A
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
CRIP2 cysteine-rich protein 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSK cathepsin K
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DUSP4 dual specificity phosphatase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR2 early growth response 2
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNB filamin B, beta
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IL6 interleukin 6
INHBA inhibin, beta A
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
LPL lipoprotein lipase
LST1 leukocyte specific transcript 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
MSRA methionine sulfoxide reductase A
MTMR11 myotubularin related protein 11
MYC v-myc avian myelocytomatosis viral oncogene homolog
NADK NAD kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
OPTN optineurin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRL platelet-derived growth factor receptor-like
PENK proenkephalin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RRAD Ras-related associated with diabetes
RSL1D1 ribosomal L1 domain containing 1
S100A12 S100 calcium binding protein A12
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC22A18 solute carrier family 22, member 18
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TFPI2 tissue factor pathway inhibitor 2
TMOD1 tropomodulin 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BLCAP bladder cancer associated protein
C7 complement component 7
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNE2 cyclin E2
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSH cathepsin H
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DKK1 dickkopf WNT signaling pathway inhibitor 1
EED embryonic ectoderm development
EIF5 eukaryotic translation initiation factor 5
FAM46C family with sequence similarity 46, member C
FANCL Fanconi anemia, complementation group L
FZD7 frizzled class receptor 7
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
LAMB1 laminin, beta 1
LBR lamin B receptor
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCAM melanoma cell adhesion molecule
MEIS2 Meis homeobox 2
MREG melanoregulin
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PHACTR2 phosphatase and actin regulator 2
PLIN2 perilipin 2
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A7 S100 calcium binding protein A7
SDC1 syndecan 1
SNX11 sorting nexin 11
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
ZWILCH zwilch kinetochore protein