BRD-K06750613_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K06750613_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BGN biglycan
C6ORF48 chromosome 6 open reading frame 48
C9ORF16 chromosome 9 open reading frame 16
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EIF4A2 eukaryotic translation initiation factor 4A2
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FNTA farnesyltransferase, CAAX box, alpha
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0430 KIAA0430
KIAA0753 KIAA0753
KIAA0907 KIAA0907
LETMD1 LETM1 domain containing 1
LOC100505650 uncharacterized LOC100505650
LOC399491
LOX lysyl oxidase
LUM lumican
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTA1 metastasis associated 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPTXR neuronal pentraxin receptor
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDE4DIP phosphodiesterase 4D interacting protein
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNKP polynucleotide kinase 3'-phosphatase
PPOX protoporphyrinogen oxidase
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
QPCT glutaminyl-peptide cyclotransferase
RAD9A RAD9 homolog A (S. pombe)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFC5 replication factor C (activator 1) 5, 36.5kDa
RIOK3 RIO kinase 3
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SORBS2 sorbin and SH3 domain containing 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
THBS2 thrombospondin 2
TMEM2 transmembrane protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRD T cell receptor delta locus
TRPS1 trichorhinophalangeal syndrome I
TSPO translocator protein (18kDa)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XBP1 X-box binding protein 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BASP1 brain abundant, membrane attached signal protein 1
C1QB complement component 1, q subcomponent, B chain
CALD1 caldesmon 1
CCND2 cyclin D2
CHGB chromogranin B
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CTGF connective tissue growth factor
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DSE dermatan sulfate epimerase
FCGBP Fc fragment of IgG binding protein
FERMT2 fermitin family member 2
FGFBP1 fibroblast growth factor binding protein 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GRB2 growth factor receptor-bound protein 2
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KCTD12 potassium channel tetramerization domain containing 12
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTF lactotransferrin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS7 mitochondrial ribosomal protein S7
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SRI sorcin
TMEM50B transmembrane protein 50B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WT1 Wilms tumor 1
Funding