BRD-K06750613_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K06750613_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGAP29 Rho GTPase activating protein 29
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
DARS aspartyl-tRNA synthetase
DBT dihydrolipoamide branched chain transacylase E2
DDIT4 DNA-damage-inducible transcript 4
FCGBP Fc fragment of IgG binding protein
FGG fibrinogen gamma chain
FN1 fibronectin 1
FNTA farnesyltransferase, CAAX box, alpha
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HNMT histamine N-methyltransferase
IER3 immediate early response 3
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
LDOC1 leucine zipper, down-regulated in cancer 1
LUM lumican
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
PDE4C phosphodiesterase 4C, cAMP-specific
PLCB4 phospholipase C, beta 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PNRC1 proline-rich nuclear receptor coactivator 1
PRAME preferentially expressed antigen in melanoma
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNMT RNA (guanine-7-) methyltransferase
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SPATA20 spermatogenesis associated 20
STC2 stanniocalcin 2
SYNM synemin, intermediate filament protein
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
AK1 adenylate kinase 1
AKAP12 A kinase (PRKA) anchor protein 12
APP amyloid beta (A4) precursor protein
ARF1 ADP-ribosylation factor 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
C2CD2 C2 calcium-dependent domain containing 2
CCND2 cyclin D2
CD58 CD58 molecule
ECD ecdysoneless homolog (Drosophila)
FBLN5 fibulin 5
GALE UDP-galactose-4-epimerase
GAS2L1 growth arrest-specific 2 like 1
GLIPR1 GLI pathogenesis-related 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KIF14 kinesin family member 14
KRT17 keratin 17, type I
LPL lipoprotein lipase
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
NAV3 neuron navigator 3
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPR3 natriuretic peptide receptor 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH7 protocadherin 7
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SRP72 signal recognition particle 72kDa
TRAC T cell receptor alpha constant
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
WFS1 Wolfram syndrome 1 (wolframin)
ZWILCH zwilch kinetochore protein
Funding