BRD-K06926592_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K06926592_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLVRB biliverdin reductase B
CA1 carbonic anhydrase I
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CPA3 carboxypeptidase A3 (mast cell)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
ETV1 ets variant 1
FBLN1 fibulin 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBD hemoglobin, delta
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFI44L interferon-induced protein 44-like
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
KAZN kazrin, periplakin interacting protein
KLHDC2 kelch domain containing 2
LIMCH1 LIM and calponin homology domains 1
LPAR1 lysophosphatidic acid receptor 1
LRRC17 leucine rich repeat containing 17
LXN latexin
MFAP4 microfibrillar-associated protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PBX1 pre-B-cell leukemia homeobox 1
PDE10A phosphodiesterase 10A
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PRDX6 peroxiredoxin 6
PRKCD protein kinase C, delta
RAP1GAP RAP1 GTPase activating protein
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SKAP2 src kinase associated phosphoprotein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SST somatostatin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb

decreased expression

Symbol Name
APOD apolipoprotein D
CADM1 cell adhesion molecule 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLDN3 claudin 3
CXCL12 chemokine (C-X-C motif) ligand 12
DLK1 delta-like 1 homolog (Drosophila)
FABP1 fatty acid binding protein 1, liver
FHL1 four and a half LIM domains 1
GNAS GNAS complex locus
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB31 RAB31, member RAS oncogene family
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SPDEF SAM pointed domain containing ETS transcription factor
THBS1 thrombospondin 1
TNC tenascin C
TUBA1A tubulin, alpha 1a
VSNL1 visinin-like 1
ZW10 zw10 kinetochore protein
Funding