BRD-K07023879_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K07023879_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADM adrenomedullin
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3ORF52 chromosome 3 open reading frame 52
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLMN calmin (calponin-like, transmembrane)
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCMR Fc fragment of IgM receptor
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
IRF1 interferon regulatory factor 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MOCOS molybdenum cofactor sulfurase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER2 period circadian clock 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKA aurora kinase A
B3GNT1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN2 calpain 2, (m/II) large subunit
CCNA2 cyclin A2
CCNF cyclin F
CCNG1 cyclin G1
CD24 CD24 molecule
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRYZ crystallin, zeta (quinone reductase)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
FNBP1 formin binding protein 1
FSTL1 follistatin-like 1
GAS2L1 growth arrest-specific 2 like 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTP1 glutathione S-transferase pi 1
HMGA2 high mobility group AT-hook 2
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MNDA myeloid cell nuclear differentiation antigen
MXRA7 matrix-remodelling associated 7
NDRG3 NDRG family member 3
NSG1 neuron specific gene family member 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PSPH phosphoserine phosphatase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RPA1 replication protein A1, 70kDa
S100A10 S100 calcium binding protein A10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYNM synemin, intermediate filament protein
TFPI2 tissue factor pathway inhibitor 2
TM9SF2 transmembrane 9 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
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