BRD-K07667918_linsitinib_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K07667918_linsitinib_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCNG2 cyclin G2
CD24 CD24 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
EFNA1 ephrin-A1
EIF3L eukaryotic translation initiation factor 3, subunit L
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSTA1 glutathione S-transferase alpha 1
H1F0 H1 histone family, member 0
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LETMD1 LETM1 domain containing 1
MARCKSL1 MARCKS-like 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PABPC3 poly(A) binding protein, cytoplasmic 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLK2 polo-like kinase 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ANOS1 anosmin 1
BST2 bone marrow stromal cell antigen 2
CDC25A cell division cycle 25A
CDKN2A cyclin-dependent kinase inhibitor 2A
DHCR7 7-dehydrocholesterol reductase
DMD dystrophin
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FGL2 fibrinogen-like 2
GJA1 gap junction protein, alpha 1, 43kDa
GRIA2 glutamate receptor, ionotropic, AMPA 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
TFRC transferrin receptor
TLR4 toll-like receptor 4
TUBB6 tubulin, beta 6 class V
Funding