BRD-K07762753_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K07762753_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
BHLHE41 basic helix-loop-helix family, member e41
CD52 CD52 molecule
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR2 early growth response 2
ENO2 enolase 2 (gamma, neuronal)
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS7 growth arrest-specific 7
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXB6 homeobox B6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
LST1 leukocyte specific transcript 1
MBNL2 muscleblind-like splicing regulator 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
P4HB prolyl 4-hydroxylase, beta polypeptide
PCSK5 proprotein convertase subtilisin/kexin type 5
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RIOK3 RIO kinase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMEM164 transmembrane protein 164
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AQP3 aquaporin 3 (Gill blood group)
BRCA1 breast cancer 1, early onset
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CTAG2 cancer/testis antigen 2
DCK deoxycytidine kinase
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
JCHAIN joining chain of multimeric IgA and IgM
KIAA1033 KIAA1033
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MKL2 MKL/myocardin-like 2
ODC1 ornithine decarboxylase 1
PKP1 plakophilin 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POU2AF1 POU class 2 associating factor 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SMAD1 SMAD family member 1
STK26 serine/threonine protein kinase 26
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
Funding