BRD-K08448573_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K08448573_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
APOD apolipoprotein D
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACE2 beta-site APP-cleaving enzyme 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTH cystathionine gamma-lyase
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GTPBP2 GTP binding protein 2
HES1 hes family bHLH transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
LMO4 LIM domain only 4
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MOCOS molybdenum cofactor sulfurase
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PPOX protoporphyrinogen oxidase
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
STC2 stanniocalcin 2
TBC1D15 TBC1 domain family, member 15
TBX3 T-box 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM47 transmembrane protein 47
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNL4B thioredoxin-like 4B
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VIM vimentin
WARS tryptophanyl-tRNA synthetase
WDR7 WD repeat domain 7
XPOT exportin, tRNA

decreased expression

Symbol Name
ALB albumin
ATF5 activating transcription factor 5
CALB1 calbindin 1, 28kDa
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL4A5 collagen, type IV, alpha 5
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
EFNB2 ephrin-B2
EPCAM epithelial cell adhesion molecule
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
GRWD1 glutamate-rich WD repeat containing 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
IGHD immunoglobulin heavy constant delta
KIAA0101 KIAA0101
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PRKCD protein kinase C, delta
RPL31 ribosomal protein L31
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
TYMS thymidylate synthetase
ZNF264 zinc finger protein 264