BRD-K08547377_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K08547377_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AEN apoptosis enhancing nuclease
AQP9 aquaporin 9
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
C8ORF4 chromosome 8 open reading frame 4
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCL1 myeloid cell leukemia 1
MICALL1 MICAL-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRPF39 pre-mRNA processing factor 39
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SESN1 sestrin 1
SFN stratifin
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM22 tripartite motif containing 22
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
VCAM1 vascular cell adhesion molecule 1
VCPKMT valosin containing protein lysine (K) methyltransferase
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCND1 cyclin D1
CCNF cyclin F
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COL4A2 collagen, type IV, alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GPSM2 G-protein signaling modulator 2
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIRA histone cell cycle regulator
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGKV1-5 immunoglobulin kappa variable 1-5
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MBNL1 muscleblind-like splicing regulator 1
MECOM MDS1 and EVI1 complex locus
MPZL2 myelin protein zero-like 2
NES nestin
NTS neurotensin
PBK PDZ binding kinase
PDAP1 PDGFA associated protein 1
PFN2 profilin 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
RHOBTB3 Rho-related BTB domain containing 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TUBB tubulin, beta class I
VCAN versican
ZMIZ1 zinc finger, MIZ-type containing 1