BRD-K08547377_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K08547377_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALB albumin
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C5AR1 complement component 5a receptor 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEP70 centrosomal protein 70kDa
CHMP4A charged multivesicular body protein 4A
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
F11R F11 receptor
FAIM Fas apoptotic inhibitory molecule
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRAMD3 GRAM domain containing 3
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HCAR3 hydroxycarboxylic acid receptor 3
HIC2 hypermethylated in cancer 2
HOXB2 homeobox B2
HOXB6 homeobox B6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
IRF6 interferon regulatory factor 6
ISL1 ISL LIM homeobox 1
ISYNA1 inositol-3-phosphate synthase 1
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
LIMK2 LIM domain kinase 2
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NID1 nidogen 1
NPTX2 neuronal pentraxin II
NXN nucleoredoxin
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLXNB2 plexin B2
PPOX protoporphyrinogen oxidase
PTPRF protein tyrosine phosphatase, receptor type, F
RAD51AP1 RAD51 associated protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RPL10 ribosomal protein L10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SALL2 spalt-like transcription factor 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SESN1 sestrin 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STON1 stonin 1
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM204 transmembrane protein 204
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF195 zinc finger protein 195
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
AK1 adenylate kinase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
IGFBP4 insulin-like growth factor binding protein 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST4 microtubule associated serine/threonine kinase family member 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MET MET proto-oncogene, receptor tyrosine kinase
MRPS2 mitochondrial ribosomal protein S2
MYLK myosin light chain kinase
NFIB nuclear factor I/B
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PRKCZ protein kinase C, zeta
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
RBM47 RNA binding motif protein 47
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC16A4 solute carrier family 16, member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SPATS2L spermatogenesis associated, serine-rich 2-like
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TNPO1 transportin 1
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB38 zinc finger and BTB domain containing 38
Funding