BRD-K08799216_pelitinib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K08799216_pelitinib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DPP4 dipeptidyl-peptidase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS1 growth arrest-specific 1
GRHPR glyoxylate reductase/hydroxypyruvate reductase
IARS isoleucyl-tRNA synthetase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF9 Kruppel-like factor 9
LMO4 LIM domain only 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAST2 microtubule associated serine/threonine kinase 2
MOCOS molybdenum cofactor sulfurase
MT1X metallothionein 1X
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFN2 profilin 2
PHF11 PHD finger protein 11
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCPEP1 serine carboxypeptidase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
WDR41 WD repeat domain 41
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AEBP1 AE binding protein 1
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C2CD2 C2 calcium-dependent domain containing 2
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL13A1 collagen, type XIII, alpha 1
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFHD2 EF-hand domain family, member D2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
FGFBP1 fibroblast growth factor binding protein 1
FN1 fibronectin 1
GPER1 G protein-coupled estrogen receptor 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP9 matrix metallopeptidase 9
NT5E 5'-nucleotidase, ecto (CD73)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLN phospholamban
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SMTN smoothelin
SQLE squalene epoxidase
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
WFDC2 WAP four-disulfide core domain 2
Funding