BRD-K09416995_LOVASTATIN_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K09416995_LOVASTATIN_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACVR1 activin A receptor, type I
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
BTBD3 BTB (POZ) domain containing 3
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CDC25B cell division cycle 25B
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTSK cathepsin K
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DPP4 dipeptidyl-peptidase 4
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GUSB glucuronidase, beta
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHDC2 kelch domain containing 2
LPAR6 lysophosphatidic acid receptor 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEF2C myocyte enhancer factor 2C
MMP2 matrix metallopeptidase 2
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPL periplakin
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
RABGAP1L RAB GTPase activating protein 1-like
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SPRED2 sprouty-related, EVH1 domain containing 2
STX1A syntaxin 1A (brain)
TCEA2 transcription elongation factor A (SII), 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIOBP TRIO and F-actin binding protein
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCAN versican
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD47 CD47 molecule
CDC123 cell division cycle 123
CFLAR CASP8 and FADD-like apoptosis regulator
CLTB clathrin, light chain B
COX11 COX11 cytochrome c oxidase copper chaperone
CTPS1 CTP synthase 1
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM60A family with sequence similarity 60, member A
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA3 GATA binding protein 3
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
LMCD1 LIM and cysteine-rich domains 1
LRRC59 leucine rich repeat containing 59
MAP2K3 mitogen-activated protein kinase kinase 3
MBNL2 muscleblind-like splicing regulator 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MOK MOK protein kinase
MRPL3 mitochondrial ribosomal protein L3
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL9 myosin, light chain 9, regulatory
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NT5DC2 5'-nucleotidase domain containing 2
ODC1 ornithine decarboxylase 1
OXTR oxytocin receptor
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRSS23 protease, serine, 23
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTRH2 peptidyl-tRNA hydrolase 2
QKI QKI, KH domain containing, RNA binding
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REEP5 receptor accessory protein 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
VCL vinculin
WWC1 WW and C2 domain containing 1
Funding