BRD-K09549677_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K09549677_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACLY ATP citrate lyase
AGTR1 angiotensin II receptor, type 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD52 CD52 molecule
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFBP1 fibroblast growth factor binding protein 1
FOXO3 forkhead box O3
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
HBP1 HMG-box transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
INSIG1 insulin induced gene 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SORBS2 sorbin and SH3 domain containing 2
SQLE squalene epoxidase
SQSTM1 sequestosome 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
CA2 carbonic anhydrase II
CX3CR1 chemokine (C-X3-C motif) receptor 1
FAIM Fas apoptotic inhibitory molecule
FCGBP Fc fragment of IgG binding protein
FGL2 fibrinogen-like 2
GJA1 gap junction protein, alpha 1, 43kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLK6 kallikrein-related peptidase 6
MSLN mesothelin
NOP16 NOP16 nucleolar protein
PAEP progestagen-associated endometrial protein
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
TOP1 topoisomerase (DNA) I
UBE2N ubiquitin-conjugating enzyme E2N
Funding