BRD-K09602097_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K09602097_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
FBN2 fibrillin 2
FRY furry homolog (Drosophila)
FST follistatin
HIST1H2BG histone cluster 1, H2bg
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
IL1RN interleukin 1 receptor antagonist
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAOA monoamine oxidase A
MCOLN1 mucolipin 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MFSD10 major facilitator superfamily domain containing 10
MXRA5 matrix-remodelling associated 5
NFE2 nuclear factor, erythroid 2
NOTCH1 notch 1
PDZK1IP1 PDZK1 interacting protein 1
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRAME preferentially expressed antigen in melanoma
PRSS3 protease, serine, 3
RBP1 retinol binding protein 1, cellular
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYMP thymidine phosphorylase
WT1 Wilms tumor 1

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNG1 cyclin G1
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHMP4A charged multivesicular body protein 4A
CLU clusterin
CNN3 calponin 3, acidic
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EBNA1BP2 EBNA1 binding protein 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM134B family with sequence similarity 134, member B
FGFR1 fibroblast growth factor receptor 1
FSCN1 fascin actin-bundling protein 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IARS isoleucyl-tRNA synthetase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT15 keratin 15, type I
LOXL1 lysyl oxidase-like 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MMP3 matrix metallopeptidase 3
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEBL nebulette
NEFH neurofilament, heavy polypeptide
OSBPL9 oxysterol binding protein-like 9
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PLA2G16 phospholipase A2, group XVI
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB40B RAB40B, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRAM1 translocation associated membrane protein 1
TRIM22 tripartite motif containing 22
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
YME1L1 YME1-like 1 ATPase
Funding