BRD-K09907482_PRL-3 Inhibitor I_PC3_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

38 genes differentially expressed following the BRD-K09907482_PRL-3 Inhibitor I_PC3_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CDA cytidine deaminase
DUSP3 dual specificity phosphatase 3
ECM1 extracellular matrix protein 1
EDN3 endothelin 3
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IL1B interleukin 1, beta
JUN jun proto-oncogene
KLK5 kallikrein-related peptidase 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NSG1 neuron specific gene family member 1
PRKCD protein kinase C, delta
RRAD Ras-related associated with diabetes
TNFRSF21 tumor necrosis factor receptor superfamily, member 21

decreased expression

Symbol Name
APP amyloid beta (A4) precursor protein
BCLAF1 BCL2-associated transcription factor 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DUSP6 dual specificity phosphatase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
IQGAP1 IQ motif containing GTPase activating protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SHOX2 short stature homeobox 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
ZIC1 Zic family member 1
Funding