BRD-K09951645_dabrafenib_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K09951645_dabrafenib_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CST1 cystatin SN
CTH cystathionine gamma-lyase
CTSB cathepsin B
CYR61 cysteine-rich, angiogenic inducer, 61
DBN1 drebrin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV5 ets variant 5
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GARS glycyl-tRNA synthetase
GLRX glutaredoxin (thioltransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER1 homer scaffolding protein 1
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA10 integrin, alpha 10
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAMB1 laminin, beta 1
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXRA8 matrix-remodelling associated 8
NOS3 nitric oxide synthase 3 (endothelial cell)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
S100A11 S100 calcium binding protein A11
SARS seryl-tRNA synthetase
SDC4 syndecan 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM34 translocase of outer mitochondrial membrane 34
TSC22D1 TSC22 domain family, member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASCL1 achaete-scute family bHLH transcription factor 1
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPU centromere protein U
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
H2AFX H2A histone family, member X
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KLK11 kallikrein-related peptidase 11
LMNB1 lamin B1
LTBP1 latent transforming growth factor beta binding protein 1
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MPC2 mitochondrial pyruvate carrier 2
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NKX3-1 NK3 homeobox 1
OLFM1 olfactomedin 1
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SQLE squalene epoxidase
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein
Funding