BRD-K09951645_dabrafenib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K09951645_dabrafenib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSM3 acyl-CoA synthetase medium-chain family member 3
AHCYL1 adenosylhomocysteinase-like 1
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
CAPG capping protein (actin filament), gelsolin-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC53 coiled-coil domain containing 53
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC3 chloride intracellular channel 3
CLINT1 clathrin interactor 1
CTSA cathepsin A
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
DNM1 dynamin 1
DYNLRB1 dynein, light chain, roadblock-type 1
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FZD6 frizzled class receptor 6
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GOLPH3L golgi phosphoprotein 3-like
GPATCH8 G patch domain containing 8
GRAMD3 GRAM domain containing 3
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
MGST3 microsomal glutathione S-transferase 3
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PTCH1 patched 1
QPRT quinolinate phosphoribosyltransferase
SCAND1 SCAN domain containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
TAPBP TAP binding protein (tapasin)
TMC5 transmembrane channel-like 5
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTC1 actin, alpha, cardiac muscle 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DES desmin
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
FAM69A family with sequence similarity 69, member A
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FST follistatin
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IPO4 importin 4
IRF8 interferon regulatory factor 8
KIAA0020 KIAA0020
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAP3 leucine aminopeptidase 3
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MAL mal, T-cell differentiation protein
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MINA MYC induced nuclear antigen
MRPL3 mitochondrial ribosomal protein L3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
NUP85 nucleoporin 85kDa
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PLN phospholamban
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POSTN periostin, osteoblast specific factor
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSIP1 PC4 and SFRS1 interacting protein 1
PUS7 pseudouridylate synthase 7 (putative)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPP40 ribonuclease P/MRP 40kDa subunit
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLN sarcolipin
SNX10 sorting nexin 10
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TPM4 tropomyosin 4
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
WDR12 WD repeat domain 12
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
Funding