BRD-K09951645_dabrafenib_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K09951645_dabrafenib_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
ATXN1 ataxin 1
AUTS2 autism susceptibility candidate 2
CADM1 cell adhesion molecule 1
CALML5 calmodulin-like 5
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CST7 cystatin F (leukocystatin)
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GPX3 glutathione peroxidase 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-B major histocompatibility complex, class I, B
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LGMN legumain
LHX2 LIM homeobox 2
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PODXL podocalyxin-like
PRNP prion protein
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RANBP2 RAN binding protein 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TF transferrin
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VDAC1 voltage-dependent anion channel 1
WAC WW domain containing adaptor with coiled-coil
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
CD24 CD24 molecule
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FBP1 fructose-1,6-bisphosphatase 1
GREM1 gremlin 1, DAN family BMP antagonist
HEBP1 heme binding protein 1
ICAM2 intercellular adhesion molecule 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
LRRN3 leucine rich repeat neuronal 3
LSR lipolysis stimulated lipoprotein receptor
MMP12 matrix metallopeptidase 12
MYB v-myb avian myeloblastosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PENK proenkephalin
PRKCA protein kinase C, alpha
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TLK2 tousled-like kinase 2
Funding