BRD-K09991945_GSK-3 Inhibitor II_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
ALB albumin
ANK2 ankyrin 2, neuronal
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C3ORF14 chromosome 3 open reading frame 14
CD36 CD36 molecule (thrombospondin receptor)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COG5 component of oligomeric golgi complex 5
COL1A1 collagen, type I, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
ESR1 estrogen receptor 1
FBXL12 F-box and leucine-rich repeat protein 12
FGF13 fibroblast growth factor 13
GCH1 GTP cyclohydrolase 1
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HEPH hephaestin
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MCTS1 malignant T cell amplified sequence 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC16 mucin 16, cell surface associated
NEBL nebulette
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXA1L oxidase (cytochrome c) assembly 1-like
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGS4 regulator of G-protein signaling 4
RPL10 ribosomal protein L10
RSL24D1 ribosomal L24 domain containing 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SFRP4 secreted frizzled-related protein 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
USP25 ubiquitin specific peptidase 25
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZFAND1 zinc finger, AN1-type domain 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACTB actin, beta
ADGRA3 adhesion G protein-coupled receptor A3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAD BCL2-associated agonist of cell death
BASP1 brain abundant, membrane attached signal protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRD3 bromodomain containing 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CTSB cathepsin B
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EZR ezrin
FAM13A family with sequence similarity 13, member A
FOXF1 forkhead box F1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LIMA1 LIM domain and actin binding 1
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCAM melanoma cell adhesion molecule
MOK MOK protein kinase
MYH11 myosin, heavy chain 11, smooth muscle
NKX3-1 NK3 homeobox 1
NLRP2 NLR family, pyrin domain containing 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRPF4 pre-mRNA processing factor 4
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RALGDS ral guanine nucleotide dissociation stimulator
REEP1 receptor accessory protein 1
RHOB ras homolog family member B
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TGFA transforming growth factor, alpha
TKTL1 transketolase-like 1
TMEM255A transmembrane protein 255A
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TUBB4B tubulin, beta 4B class IVb
UGCG UDP-glucose ceramide glucosyltransferase
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
ZMYND8 zinc finger, MYND-type containing 8
Funding