BRD-K09991945_GSK-3 Inhibitor II_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
ALB albumin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF54 chromosome 1 open reading frame 54
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CFLAR CASP8 and FADD-like apoptosis regulator
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EDN1 endothelin 1
EGF epidermal growth factor
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FGF1 fibroblast growth factor 1 (acidic)
FGFR3 fibroblast growth factor receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL32 interleukin 32
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
PDLIM5 PDZ and LIM domain 5
PDZD2 PDZ domain containing 2
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PSAT1 phosphoserine aminotransferase 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SYBU syntabulin (syntaxin-interacting)
TMEM176B transmembrane protein 176B
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRA3 adhesion G protein-coupled receptor A3
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOA aldolase A, fructose-bisphosphate
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
CCNI cyclin I
COL6A3 collagen, type VI, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTTN cortactin
EFHC1 EF-hand domain (C-terminal) containing 1
FAM46A family with sequence similarity 46, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FUS FUS RNA binding protein
GEM GTP binding protein overexpressed in skeletal muscle
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2BK histone cluster 1, H2bk
HMGN3 high mobility group nucleosomal binding domain 3
HOXA5 homeobox A5
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP6 insulin-like growth factor binding protein 6
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MRPL28 mitochondrial ribosomal protein L28
MSRB2 methionine sulfoxide reductase B2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCP4 Purkinje cell protein 4
PFKP phosphofructokinase, platelet
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCB protein kinase C, beta
PRSS2 protease, serine, 2 (trypsin 2)
QKI QKI, KH domain containing, RNA binding
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SKAP2 src kinase associated phosphoprotein 2
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SMYD3 SET and MYND domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSFA2 sperm specific antigen 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TM4SF1 transmembrane 4 L six family member 1
TSC22D1 TSC22 domain family, member 1
TUSC3 tumor suppressor candidate 3
VWA5A von Willebrand factor A domain containing 5A
YME1L1 YME1-like 1 ATPase
ZMYND11 zinc finger, MYND-type containing 11
Funding