BRD-K10010115_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K10010115_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
CD24 CD24 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
CRABP2 cellular retinoic acid binding protein 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CREM cAMP responsive element modulator
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUOX2 dual oxidase 2
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LMOD1 leiomodin 1 (smooth muscle)
MMP1 matrix metallopeptidase 1
MYH11 myosin, heavy chain 11, smooth muscle
MZB1 marginal zone B and B1 cell-specific protein
PALLD palladin, cytoskeletal associated protein
PLAU plasminogen activator, urokinase
PLS1 plastin 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SMAD3 SMAD family member 3
SORBS2 sorbin and SH3 domain containing 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TNS3 tensin 3
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BEX1 brain expressed, X-linked 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHMP4A charged multivesicular body protein 4A
CLEC11A C-type lectin domain family 11, member A
EMP3 epithelial membrane protein 3
FAM46A family with sequence similarity 46, member A
GOLGA8A golgin A8 family, member A
HOXC6 homeobox C6
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
PLK1 polo-like kinase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
Funding