BRD-K10143126_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K10143126_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASCL1 achaete-scute family bHLH transcription factor 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CEP57 centrosomal protein 57kDa
CHN1 chimerin 1
COL9A2 collagen, type IX, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CXADR coxsackie virus and adenovirus receptor
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENSA endosulfine alpha
FAM129A family with sequence similarity 129, member A
FBXL12 F-box and leucine-rich repeat protein 12
FOXG1 forkhead box G1
GRB7 growth factor receptor-bound protein 7
H2AFV H2A histone family, member V
HIST1H2BG histone cluster 1, H2bg
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
MTSS1 metastasis suppressor 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PBX3 pre-B-cell leukemia homeobox 3
SFTPA2 surfactant protein A2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SQLE squalene epoxidase
TBX3 T-box 3
TMSB15A thymosin beta 15a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMD1 adenosylmethionine decarboxylase 1
BCL2A1 BCL2-related protein A1
BTBD3 BTB (POZ) domain containing 3
CAV1 caveolin 1, caveolae protein, 22kDa
CD69 CD69 molecule
COG5 component of oligomeric golgi complex 5
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLD dihydrolipoamide dehydrogenase
EGR2 early growth response 2
FBN2 fibrillin 2
FGF9 fibroblast growth factor 9
FXYD2 FXYD domain containing ion transport regulator 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
KYNU kynureninase
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
MSX1 msh homeobox 1
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NID2 nidogen 2 (osteonidogen)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
PDZK1 PDZ domain containing 1
PLAGL1 pleiomorphic adenoma gene-like 1
PMPCB peptidase (mitochondrial processing) beta
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TGM2 transglutaminase 2
TRIP6 thyroid hormone receptor interactor 6
Funding