BRD-K10705233_GW405833 hydrochloride_HCC15_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_HCC15_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C2 complement component 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCK cholecystokinin
CD1E CD1e molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FOXG1 forkhead box G1
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GOLGA4 golgin A4
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IRF6 interferon regulatory factor 6
JCHAIN joining chain of multimeric IgA and IgM
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MZB1 marginal zone B and B1 cell-specific protein
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLCL1 phospholipase C-like 1
POU2AF1 POU class 2 associating factor 1
RGCC regulator of cell cycle
RTN1 reticulon 1
S100P S100 calcium binding protein P
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC1 syndecan 1
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADRB2 adrenoceptor beta 2, surface
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AUTS2 autism susceptibility candidate 2
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFNB2 ephrin-B2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM46A family with sequence similarity 46, member A
FBXO11 F-box protein 11
GPX3 glutathione peroxidase 3
HSPA1A heat shock 70kDa protein 1A
KCTD12 potassium channel tetramerization domain containing 12
LDHB lactate dehydrogenase B
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MARCKS myristoylated alanine-rich protein kinase C substrate
NME4 NME/NM23 nucleoside diphosphate kinase 4
PRDX2 peroxiredoxin 2
RBP1 retinol binding protein 1, cellular
S100A11 S100 calcium binding protein A11
SFRP1 secreted frizzled-related protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
ZBTB38 zinc finger and BTB domain containing 38
Funding