BRD-K10705233_GW405833 hydrochloride_HCC515_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_HCC515_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
FGL2 fibrinogen-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
SPP1 secreted phosphoprotein 1
STX1A syntaxin 1A (brain)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKB creatine kinase, brain
CSRP2 cysteine and glycine-rich protein 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FANCI Fanconi anemia, complementation group I
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPATCH8 G patch domain containing 8
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGB2 high mobility group box 2
IGFBP3 insulin-like growth factor binding protein 3
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NID1 nidogen 1
NUSAP1 nucleolar and spindle associated protein 1
PLK1 polo-like kinase 1
RRM2 ribonucleotide reductase M2
SEPT11 septin 11
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
ZWINT ZW10 interacting kinetochore protein
Funding