BRD-K10705233_GW405833 hydrochloride_PC3_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_PC3_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BGN biglycan
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDN3 endothelin 3
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GARS glycyl-tRNA synthetase
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IL32 interleukin 32
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
LARP6 La ribonucleoprotein domain family, member 6
LMCD1 LIM and cysteine-rich domains 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RB1CC1 RB1-inducible coiled-coil 1
REG1B regenerating islet-derived 1 beta
RHOQ ras homolog family member Q
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HMGN3 high mobility group nucleosomal binding domain 3
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IRX5 iroquois homeobox 5
KIF20A kinesin family member 20A
LBR lamin B receptor
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
ODC1 ornithine decarboxylase 1
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
RRM2 ribonucleotide reductase M2
SKAP2 src kinase associated phosphoprotein 2
SMAD6 SMAD family member 6
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
UBE2S ubiquitin-conjugating enzyme E2S
Funding