BRD-K10705233_GW405833 hydrochloride_RMGI_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_RMGI_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ANXA5 annexin A5
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
BBX bobby sox homolog (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC4 chloride intracellular channel 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COCH cochlin
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHCR24 24-dehydrocholesterol reductase
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FAM171A1 family with sequence similarity 171, member A1
FKBP5 FK506 binding protein 5
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXC1 forkhead box C1
FOXO3 forkhead box O3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GMDS GDP-mannose 4,6-dehydratase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ITM2A integral membrane protein 2A
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5D lysine (K)-specific demethylase 5D
KLF5 Kruppel-like factor 5 (intestinal)
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
LRRC16A leucine rich repeat containing 16A
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MYH11 myosin, heavy chain 11, smooth muscle
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
PCP4 Purkinje cell protein 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLN phospholamban
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SAP30 Sin3A-associated protein, 30kDa
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STK39 serine threonine kinase 39
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM2 tripartite motif containing 2
TSPAN8 tetraspanin 8
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ANXA6 annexin A6
AZU1 azurocidin 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CDC20 cell division cycle 20
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CST7 cystatin F (leukocystatin)
CTAG2 cancer/testis antigen 2
DEFA4 defensin, alpha 4, corticostatin
EDN1 endothelin 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GREM1 gremlin 1, DAN family BMP antagonist
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LMNB1 lamin B1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NLRP2 NLR family, pyrin domain containing 2
PLSCR3 phospholipid scramblase 3
PMM2 phosphomannomutase 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTPRK protein tyrosine phosphatase, receptor type, K
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
SHOX2 short stature homeobox 2
SLC2A4RG SLC2A4 regulator
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
SULF1 sulfatase 1
TCF4 transcription factor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TRIB2 tribbles pseudokinase 2
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)
Funding