BRD-K10705233_GW405833 hydrochloride_SKLU1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_SKLU1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADIPOQ adiponectin, C1Q and collagen domain containing
ANPEP alanyl (membrane) aminopeptidase
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CBS cystathionine-beta-synthase
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
COL15A1 collagen, type XV, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYTIP cytohesin 1 interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
FBXL12 F-box and leucine-rich repeat protein 12
FKBP11 FK506 binding protein 11, 19 kDa
G0S2 G0/G1 switch 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPM6B glycoprotein M6B
GPR171 G protein-coupled receptor 171
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
KCTD14 potassium channel tetramerization domain containing 14
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LBP lipopolysaccharide binding protein
LRRC41 leucine rich repeat containing 41
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MX1 MX dynamin-like GTPase 1
NAMPT nicotinamide phosphoribosyltransferase
NANOG Nanog homeobox
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
NPC1 Niemann-Pick disease, type C1
PAEP progestagen-associated endometrial protein
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PTK2 protein tyrosine kinase 2
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RTN2 reticulon 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SQRDL sulfide quinone reductase-like (yeast)
STC1 stanniocalcin 1
TF transferrin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM35 transmembrane protein 35
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VCAN versican
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AUTS2 autism susceptibility candidate 2
BIK BCL2-interacting killer (apoptosis-inducing)
CAT catalase
CCDC92 coiled-coil domain containing 92
CCNB2 cyclin B2
CCND1 cyclin D1
CLIC4 chloride intracellular channel 4
COASY CoA synthase
COL3A1 collagen, type III, alpha 1
COL4A2 collagen, type IV, alpha 2
COMMD3 COMM domain containing 3
CPVL carboxypeptidase, vitellogenic-like
CST1 cystatin SN
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
GADD45B growth arrest and DNA-damage-inducible, beta
GPX2 glutathione peroxidase 2
GTF2H5 general transcription factor IIH, polypeptide 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
KANK2 KN motif and ankyrin repeat domains 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAP7 microtubule-associated protein 7
MMP7 matrix metallopeptidase 7
MXRA7 matrix-remodelling associated 7
MYO6 myosin VI
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OAT ornithine aminotransferase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDHX pyruvate dehydrogenase complex, component X
PLS1 plastin 1
PMM2 phosphomannomutase 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRPF4 pre-mRNA processing factor 4
RAB4A RAB4A, member RAS oncogene family
RFC2 replication factor C (activator 1) 2, 40kDa
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SRSF3 serine/arginine-rich splicing factor 3
STK39 serine threonine kinase 39
TESC tescalcin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
Funding