BRD-K10705233_GW405833 hydrochloride_SW948_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_SW948_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CP ceruloplasmin (ferroxidase)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYBPC1 myosin binding protein C, slow type
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
PCP4 Purkinje cell protein 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PNKP polynucleotide kinase 3'-phosphatase
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
RHOQ ras homolog family member Q
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNT1 troponin T type 1 (skeletal, slow)
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
CAPN3 calpain 3, (p94)
CDC20 cell division cycle 20
CLC Charcot-Leyden crystal galectin
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CXCL14 chemokine (C-X-C motif) ligand 14
EDF1 endothelial differentiation-related factor 1
IDI1 isopentenyl-diphosphate delta isomerase 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MRPS2 mitochondrial ribosomal protein S2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
PTCH1 patched 1
RBP1 retinol binding protein 1, cellular
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF6 serine/arginine-rich splicing factor 6
TPD52 tumor protein D52
VCAM1 vascular cell adhesion molecule 1
Funding