BRD-K10705233_GW405833 hydrochloride_U937_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_U937_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ARG2 arginase 2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BGN biglycan
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
C6ORF48 chromosome 6 open reading frame 48
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP70 centrosomal protein 70kDa
CLIC3 chloride intracellular channel 3
CLIC4 chloride intracellular channel 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CPNE3 copine III
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DERA deoxyribose-phosphate aldolase (putative)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAIM Fas apoptotic inhibitory molecule
GJA1 gap junction protein, alpha 1, 43kDa
GPR137B G protein-coupled receptor 137B
GTPBP8 GTP-binding protein 8 (putative)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KLHDC2 kelch domain containing 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LDB2 LIM domain binding 2
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
MFAP2 microfibrillar-associated protein 2
MTUS1 microtubule associated tumor suppressor 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NID2 nidogen 2 (osteonidogen)
NMRK1 nicotinamide riboside kinase 1
NMU neuromedin U
NOTCH1 notch 1
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PHF1 PHD finger protein 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
RAD51AP1 RAD51 associated protein 1
RGS13 regulator of G-protein signaling 13
RGS5 regulator of G-protein signaling 5
S100A11 S100 calcium binding protein A11
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SALL1 spalt-like transcription factor 1
SARS seryl-tRNA synthetase
SDC1 syndecan 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SKAP2 src kinase associated phosphoprotein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMC1A structural maintenance of chromosomes 1A
SNX2 sorting nexin 2
STAMBP STAM binding protein
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM35 transmembrane protein 35
TMEM47 transmembrane protein 47
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VSNL1 visinin-like 1
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
WNT5B wingless-type MMTV integration site family, member 5B
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
AKAP1 A kinase (PRKA) anchor protein 1
AMD1 adenosylmethionine decarboxylase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCND3 cyclin D3
CDC25A cell division cycle 25A
CHL1 cell adhesion molecule L1-like
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPR88 G protein-coupled receptor 88
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
KRT7 keratin 7, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPL lipoprotein lipase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAT2A methionine adenosyltransferase II, alpha
MSLN mesothelin
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
PPIF peptidylprolyl isomerase F
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PTDSS1 phosphatidylserine synthase 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TPM4 tropomyosin 4
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
Funding