BRD-K10882151_BO2 (inhibits RAD51)_A549_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_A549_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AKAP13 A kinase (PRKA) anchor protein 13
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMDHD2 amidohydrolase domain containing 2
ANXA5 annexin A5
AREG amphiregulin
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAPN2 calpain 2, (m/II) large subunit
CCDC53 coiled-coil domain containing 53
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP5 dual specificity phosphatase 5
EFHD1 EF-hand domain family, member D1
ENO2 enolase 2 (gamma, neuronal)
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GOLM1 golgi membrane protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
JMJD6 jumonji domain containing 6
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
NPC1 Niemann-Pick disease, type C1
PDGFRL platelet-derived growth factor receptor-like
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RGS2 regulator of G-protein signaling 2
RNF167 ring finger protein 167
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SIX1 SIX homeobox 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
STXBP1 syntaxin binding protein 1
TMEM8A transmembrane protein 8A
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WBP2 WW domain binding protein 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ATF5 activating transcription factor 5
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD1E CD1e molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GRWD1 glutamate-rich WD repeat containing 1
HES1 hes family bHLH transcription factor 1
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
INTS3 integrator complex subunit 3
KIF20A kinesin family member 20A
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
NAV3 neuron navigator 3
NDP Norrie disease (pseudoglioma)
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5DC2 5'-nucleotidase domain containing 2
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
RBM3 RNA binding motif (RNP1, RRM) protein 3
S100A7 S100 calcium binding protein A7
SCGB2A1 secretoglobin, family 2A, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAT1 signal transducer and activator of transcription 1, 91kDa
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
ZNF512B zinc finger protein 512B
Funding