BRD-K10882151_BO2 (inhibits RAD51)_H1299_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_H1299_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ARMCX2 armadillo repeat containing, X-linked 2
ATM ATM serine/threonine kinase
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CALR calreticulin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DOK5 docking protein 5
FOLR1 folate receptor 1 (adult)
GCLM glutamate-cysteine ligase, modifier subunit
GUSBP11 glucuronidase, beta pseudogene 11
H2AFV H2A histone family, member V
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KYNU kynureninase
LCN2 lipocalin 2
LTBP1 latent transforming growth factor beta binding protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MZB1 marginal zone B and B1 cell-specific protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
POU2AF1 POU class 2 associating factor 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTN pleiotrophin
RGS3 regulator of G-protein signaling 3
RTN1 reticulon 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX13 sorting nexin 13
SULF1 sulfatase 1
TBXA2R thromboxane A2 receptor
TMEM41B transmembrane protein 41B
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCNA1 cyclin A1
CCND2 cyclin D2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CELF2 CUGBP, Elav-like family member 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
KLF10 Kruppel-like factor 10
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LRRN3 leucine rich repeat neuronal 3
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PALLD palladin, cytoskeletal associated protein
PLAGL1 pleiomorphic adenoma gene-like 1
PTMA prothymosin, alpha
PTX3 pentraxin 3, long
PURA purine-rich element binding protein A
QKI QKI, KH domain containing, RNA binding
RHOBTB3 Rho-related BTB domain containing 3
S100A10 S100 calcium binding protein A10
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRP72 signal recognition particle 72kDa
TCF4 transcription factor 4
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPAN5 tetraspanin 5
ZBTB18 zinc finger and BTB domain containing 18
Funding