BRD-K10882151_BO2 (inhibits RAD51)_HCC515_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_HCC515_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CALCOCO2 calcium binding and coiled-coil domain 2
CD163 CD163 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST1 cystatin SN
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
KLHL24 kelch-like family member 24
KYNU kynureninase
LHFPL2 lipoma HMGIC fusion partner-like 2
MERTK MER proto-oncogene, tyrosine kinase
PCDH9 protocadherin 9
PIR pirin (iron-binding nuclear protein)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RGS2 regulator of G-protein signaling 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
STAB1 stabilin 1
STX1A syntaxin 1A (brain)
TXNRD1 thioredoxin reductase 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ASRGL1 asparaginase like 1
BZW2 basic leucine zipper and W2 domains 2
C3 complement component 3
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
DHFR dihydrofolate reductase
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
KIAA0101 KIAA0101
LAMB1 laminin, beta 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein
Funding