BRD-K10882151_BO2 (inhibits RAD51)_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACAA2 acetyl-CoA acyltransferase 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DMBT1 deleted in malignant brain tumors 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
GALE UDP-galactose-4-epimerase
GRB10 growth factor receptor-bound protein 10
HIC2 hypermethylated in cancer 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LIMCH1 LIM and calponin homology domains 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1M metallothionein 1M
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SECISBP2L SECIS binding protein 2-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK26 serine/threonine protein kinase 26
TPBG trophoblast glycoprotein
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANO1 anoctamin 1, calcium activated chloride channel
C7 complement component 7
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
COG2 component of oligomeric golgi complex 2
COL1A2 collagen, type I, alpha 2
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CYC1 cytochrome c-1
DUSP4 dual specificity phosphatase 4
FN1 fibronectin 1
G0S2 G0/G1 switch 2
HES1 hes family bHLH transcription factor 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOC100505650 uncharacterized LOC100505650
LUM lumican
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MRPS12 mitochondrial ribosomal protein S12
MSH6 mutS homolog 6
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SCEL sciellin
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TRIM28 tripartite motif containing 28
TSPAN6 tetraspanin 6
Funding