BRD-K10882151_BO2 (inhibits RAD51)_SKM1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_SKM1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADCY2 adenylate cyclase 2 (brain)
ADIRF adipogenesis regulatory factor
AMDHD2 amidohydrolase domain containing 2
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BGN biglycan
CCL2 chemokine (C-C motif) ligand 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN3 claudin 3
CLEC5A C-type lectin domain family 5, member A
CLIC4 chloride intracellular channel 4
CP ceruloplasmin (ferroxidase)
CRELD2 cysteine-rich with EGF-like domains 2
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EIF5 eukaryotic translation initiation factor 5
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
FXR1 fragile X mental retardation, autosomal homolog 1
GAL galanin/GMAP prepropeptide
GNAS GNAS complex locus
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HPCAL1 hippocalcin-like 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LSR lipolysis stimulated lipoprotein receptor
MAP7 microtubule-associated protein 7
MEST mesoderm specific transcript
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MZB1 marginal zone B and B1 cell-specific protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRDX4 peroxiredoxin 4
PTX3 pentraxin 3, long
RHOC ras homolog family member C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
SYNJ2 synaptojanin 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52L2 tumor protein D52-like 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACACB acetyl-CoA carboxylase beta
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY1 adenylate cyclase 1 (brain)
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
C1ORF116 chromosome 1 open reading frame 116
C7 complement component 7
CCND2 cyclin D2
CES1 carboxylesterase 1
CHSY1 chondroitin sulfate synthase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPM carboxypeptidase M
CTSG cathepsin G
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ESR1 estrogen receptor 1
FAM198B family with sequence similarity 198, member B
FBLN1 fibulin 1
FBXO11 F-box protein 11
FLRT2 fibronectin leucine rich transmembrane protein 2
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPM6A glycoprotein M6A
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HAL histidine ammonia-lyase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JARID2 jumonji, AT rich interactive domain 2
KIF5C kinesin family member 5C
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MMP12 matrix metallopeptidase 12
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOTCH2 notch 2
NT5DC2 5'-nucleotidase domain containing 2
PLAT plasminogen activator, tissue
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
ZNF185 zinc finger protein 185 (LIM domain)
Funding