BRD-K10882151_BO2 (inhibits RAD51)_SW620_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_SW620_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNN3 calponin 3, acidic
CRYAB crystallin, alpha B
CTSZ cathepsin Z
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
HEPH hephaestin
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KRT6B keratin 6B, type II
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1F metallothionein 1F
MT1M metallothionein 1M
NID2 nidogen 2 (osteonidogen)
NMRK1 nicotinamide riboside kinase 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A4 solute carrier family 16, member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBX3 T-box 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TUBB6 tubulin, beta 6 class V
UPP1 uridine phosphorylase 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
APMAP adipocyte plasma membrane associated protein
BLNK B-cell linker
CTSH cathepsin H
GNAS GNAS complex locus
GPRC5B G protein-coupled receptor, class C, group 5, member B
IGHM immunoglobulin heavy constant mu
KIF20A kinesin family member 20A
NT5DC2 5'-nucleotidase domain containing 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
PTCH1 patched 1
RAD21 RAD21 homolog (S. pombe)
RBP4 retinol binding protein 4, plasma
UBL3 ubiquitin-like 3
VSNL1 visinin-like 1
ZNF185 zinc finger protein 185 (LIM domain)
Funding